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Outcome data and multivariate analysis of Upfront Surgery Group

Journal: Annals of surgery

Article Title: Timing but not patterns of recurrence are different between node-negative and node-positive resected pancreatic cancer

doi: 10.1097/SLA.0000000000003123

Figure Lengend Snippet: Outcome data and multivariate analysis of Upfront Surgery Group

Article Snippet: Importantly, lymph node status and lymph node ratio were not independently associated with local versus distant recurrence ( ). table ft1 table-wrap mode="anchored" t5 Table 2: caption a7 Total N= 394 pN0 N=109 pN1 N=285 Univariate FOLLOW-UP DATA-UPFRONT SURGERY GROUP Median/N IQR/% Median/N IQR/% Median/N IQR/% p Overall Survival 18 (10–34) 25 (11–45) 16 (10–29) 0.000 Disease free survival 11 (6–23) 16 (7–36) 10 (5–20) 0.000 Recurrence 278 (71%) 60 (55%) 218 (77%) 0.000 Local 66 (24%) 16 (27%) 50 (23%) 0.672 Distant 172 (62%) 37 (63%) 135 (62%) 0.553 Lung only 42 (24%) 8 (22%) 34 (25%) 0.718 Liver only 67 (39%) 18 (49%) 49 (36%) Lung & Liver 11 (6%) 1 (3%) 10 (7%) Other/multiple distant sites 52 (30%) 10 (27%) 42 (32%) Both 38 (14%) 6 (10%) 32 (15%) 0.292 Open in a separate window RECURRENCE univariate (Chi-square) Multivariate (Logistic regression) Factor p OR p Age 0.136 0.730 Sex 0.103 0.203 Type of Pancreatectomy 0.976 not included pN1 0.000 1.349 – 4.496 0.003 Lymph-node ratio <0.3 0.004 1.415 – 16.398 0.012 Preoperative CA 19–9 <37U/ml 0.043 0.061 T-status 0.022 0.464 R0 0.014 0.203 Adjuvant Chemoradiation 0.143 not included Adjuvant Chemotherapy alone 0.759 not included Open in a separate window LOCAL RECURRENCE Univariate (Chi-square) Multivariate (Logistic regression) Factor p OR p Age 0.372 0.221 Sex 0.259 0.225 Type of Pancreatectomy 0.649 not included pN1 0.548 not included Lymph node rate <0.3 0.503 not included Preoperative CA 19–9 <37 U/ml 0.795 not included T-status 0.456 not included R0 0.035 1.040 – 3.307 0.033 Adjuvant Chemoradiation 0.810 not included Adjuvant Chemotherapy alone 0.742 not included Open in a separate window DISTANT RECURRENCE Univariate (Chi-square) Multivariate (Logistic regression) Factor p OR p Age 0.863 0.912 Sex 0.459 0.853 Type of Pancreatectomy 0.646 not included pN1 0.971 not included Lymph node rate <0.3 0.793 not included Preoperative CA 19–9 <37 U/ml 0.548 not included T-status 0.436 not included R0 0.005 0.306 – 0.958 0.005 Adjuvant Chemoradiation 0.626 not included Adjuvant Chemotherapy alone 0.467 not included Open in a separate window Outcome data and multivariate analysis of Upfront Surgery Group Propensity-Score Matching Due to the differences between pN0 and pN1 patients, propensity-score matching was performed (see methods ) ( ).

Techniques: